23 Jul Preparation method of injectable aquagel based on polyaspartic acid derivative
Abstract
The invention discloses a preparation method of injectable aquagel based on a polyaspartic acid derivative. The method comprises the following steps of: undergoing a thermal polycondensation reaction by taking L-aspartic acid as a raw material, taking phosphoric acid as a catalyst and taking a mixed solvent of sulfolane and 1,3,5-trimethylbenzene as a reaction solvent to obtain polysuccinimide, and undergoing a ring-opening reaction by attacking with a hydrazine hydrate serving as a nucleophilic reagent to obtain a polyaspartamide hydrate; making 3-aminopropylene glycol and ethanol amine undergo a ring-opening reaction with polysuccinimide in sequence to obtain poly-3-amino-1,2-propylene glycol-modified poly(2-hydroxyethyl asparagine), and adding sodium periodate for undergoing an oxidation reaction to prepare formyl-modified poly(2-hydroxyethyl asparagine); and dissolving two prepared products into a phosphoric acid buffer solution respectively, and mixing the two solutions to formedaquagel. The preparation method disclosed by the invention has the advantages of easiness for implementing, low manufacturing cost and short gel forming time; and the injectable aquagel can be widelyapplied to medicament carriers and tissue engineering bracket materials.
Year: 2012
Country: CN
Doc No: 102617867