23 Jul Preparation Method of Hyaluronate Fiber by Melt-Spinning and Hyaluronate Fiber Prepared Thereof
Abstract
The present invention relates hyaluronate fiber, and more specifically, to hyaluronate fiber capable of being used in surgical suture, cosmetic filler, lifting thread, scaffold for tissue engineering, etc. According to the present invention, a method of manufacturing hyaluronate fiber by melt-spinning comprises the following steps: (a) adjusting the moisture content of hyaluronate with a molecular weight of 500 to 3,000 kDa within a range of 5 to 20%; (b) inserting the hyaluronate of which the moisture content is adjusted into a melt-spinning apparatus, heating the hyaluronate at 150 to 200C, and then performing spinning at high pressure to manufacture hyaluronate fiber; and (c) soaking the hyaluronate fiber in an aqueous ethanol solution to harden the surface thereof. According to the present invention, since the hyaluronate fiber is made of the hyaluronate as a main component, safety and biocompatibility are excellent. Moreover, the hyaluronate fiber is free from microorganism contamination when compared to general liquid hydrogel product, and is easy to be managed and used, and can thus be used as a material for tissue repair. Also, since the hyaluronate fiber is a solid type product, the volume is quite less with respect to the concentration of the hyaluronate, and thus can minimize pain and inconvenience of a patient when the hyaluronate fiber is injected inside the body, thereby maximizing curing effect.
Year: 2017
Country: KR
Doc No: 101709608