23 Jul Preparation method of high-flexibility amphoteric ionic hydrogel
Abstract
The invention discloses a preparation method of high-flexibility amphoteric ionic hydrogel. By changing the concentration of [2-(methacryloyloxy)ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide monomers, cross-linking agents and initiators, the high-flexibility amphoteric ionic SBMA hydrogel is obtained. The SBMA hydrogel prepared through the method has good mechanical property, protein adsorption resistance and cell adsorption performance through interaction of a large number of positive and negative charges of SB units, and meanwhile thermosensitivity and saline ion responding performance and self-restoration performance are achieved. Application of hydrogel based on amphoteric ions in the field of biomedical tissue engineering can be further expanded, and particularly in the fields, where certain mechanical strength is needed, such as artificial joints, blood vessels and the like. At the same time, the preparation method avoids the situation that traditionally, an amphoteric ionic SBMA main chain is modified through grafting, operation is easier, and industrialization of the whole process is easy.
Year: 2016
Country: CN
Doc No: 105295073