23 Jul Preparation method of drug and protein sustained-release alginate hybrid gel
Abstract
The invention provides a preparation method of drug and protein sustained-release alginate hybrid gel. The preparation method comprises the steps of preparing calcium alginate hydrogel, then soaking the calcium alginate hydrogel in inorganic salt solutions including trisodium phosphate, diammonium hydrogen phosphate, sodium silicate, sodium carbonate, sodium oxalate and the like at certain concentration to swell for a certain period of time, and soaking the swelled calcium alginate hydrogel into an aqueous solution of drugs and proteins with calcium ions at certain concentration for crosslinking for a period of time, thus obtaining the drug and protein sustained-release alginate hybrid gel. The calcium alginate hydrogel disclosed by the invention can be in the shape of a membrane, a microballoon, a fiber and the like. The method disclosed by the invention is simple to operate and does not adopt any poisonous and harmful solvent; the activity of the immobilized protein is high; the materials are good in biocompatibility; and the drug and protein sustained-release alginate hybrid gel is good in slow release performance, and has good application prospect in the fields of tissue engineering, controlled release, medicine and health, and the like.
Year: 2013
Country: CN
Doc No: 103040727