23 Jul Preparation method of composite bone tissue engineering stent material
Abstract
The invention relates to a preparation method of a composite bone tissue engineering stent material. The preparation method comprises the following steps: 1) preparing zinc ion sustained-release hydroxyapatite; 2) adding the zinc ion sustained-release hydroxyapatite obtained in the step 1) to a chitosan solution, stirring and mixing uniformly and adjusting the pH to obtain a chitosan/hydroxyapatite suspension; 3) slowly adding the suspension obtained in the step 2) to a silk fibroin solution to obtain a mixture; 4) injecting the mixture obtained in the step 3) into a mold, conducting freeze drying, immersing the mold in an anhydrous methanol and sodium hydroxide solution h, rinsing with deionized water and conducting freeze drying again to obtain a final composite stent material. The composite bone tissue engineering stent material has good biocompatibility, degradable controllability and good formability, and can be used for treating bone defects.
Year: 2019
Country: CN
Doc No: 109758609