23 Jul Preparation method of collagen/hydroxyapatite composite bracket material cross-linked with chondroitin sulfate
Abstract
The invention relates to a preparation method of a collagen/hydroxyapatite composite bracket material cross-linked with chondroitin sulfate. The method comprises the following steps of: uniformly pre-mixing the chondroitin sulfate with the collagen and precipitating to prepare collagen/hydroxyapatite slurry containing the chondroitin sulfate; foaming, freezing and drying the slurry to obtain a three-dimensional porous bracket material; and finally, carrying out cross-linking by a cross-linking agent to construct a collagen/hydroxyapatite composite bracket cross-linked with the chondroitin sulfate. According to the preparation method of the collagen/hydroxyapatite composite bracket material cross-linked with chondroitin sulfate, the technical process is simple and a pore of a porous bracket is controllable; the cross-linking effect is accelerated through a way of pre-mixing and then cross-linking, the mechanical strength of the bracket is enhanced, reagents utilized in the whole process are safe and non-toxic and the biocompatibility is high, so that the preparation method is a method which is applicable to the preparation of tissue engineering materials.
Year: 2012
Country: CN
Doc No: 102532585