23 Jul Preparation method of COL/PEG@CaP biomineralization multilayer film
Abstract
The invention discloses a preparation method of a COL/PEG@CaP biomineralization multilayer film. According to the preparation method, titanium alloy is taken as a substrate, the surface adhesiveness of the titanium alloy is improved with PDA; on the PDA modified titanium alloy substrate, COL and PEG are taken as polyelectrolytes, layer-by-layer self-assembly technology is adopted to prepare a COL/PEG self-assembled multilayer film; and at last, the COL/PEG@CaP biomineralization multilayer film is prepared through biomineralization. The COL/PEG@CaP biomineralization multilayer film prepared bythe invention can effectively improve the biotoxicity of inorganic particles in vivo; the preparation process is simple, low in cost, short in period and suitable for mass production, and has a wide application prospect; the prepared (COL/PEG)@CaP mineralized film has the functions of drug loading and release, osteoblast directional differentiation control and cell differentiation degree detection, and has a wide application prospect in the field of tissue engineering.
Year: 2020
Country: CN
Doc No: 110734646