23 Jul Preparation method of cohesive composite microsphere porous scaffolds
Abstract
The invention discloses a preparation method of cohesive composite microsphere porous scaffolds, which comprises the steps as follows: 1) nano hydroxyapatite and polylactic acid are adopted as raw materials, and composite microspheres are obtained by ultrasonic blending, suspension balling, solvent volatilization and freeze drying; and 2) the composite microspheres are subjected to grain size screening, mold feeding, air flow smoothening, polylactic acid solution dropwise adding and cohesion, solvent volatilization by air flow, vacuum heat insulation and sintering, demoulding and washing so asto obtain the porous scaffolds. The preparation method has simple process; the porosity factor of the composite microsphere is high; the aperture of the scaffold and the porosity factor can be adjusted; the moulding of the scaffold is convenient; the shape designability is strong; other cohesive phases are not introduced; and the heating time at high temperature is short. The prepared scaffold has good three-dimensional interlocking pores, good mechanical property and biocompatibility, can meet the demands of tissue engineering scaffold materials, and has potential and wide practical value inthe field of tissue repair in bone tissue engineering.
Year: 2009
Country: CN
Doc No: 101579539