23 Jul Preparation method of coaxial composite-structure bone tissue engineering scaffold
Abstract
The invention relates to a preparation method of a coaxial composite-structure bone tissue engineering scaffold. The preparation method comprises the following steps of based on a low-temperature deposition manufacture technology, by a pneumatic feeding coaxial nozzle structure, respectively applying air pressure in a shell charging barrel containing gelatin as a shell material and a core charging barrel containing beta-tricalcium phosphate and sodium alginate as core materials so that the shell solution and the core solution are extruded by two coaxial nozzles having different diameters and the extrudate is deposited on a three degree-of-freedom moving receiving plate, carrying out order overlaying to obtain a bone tissue engineering scaffold having a three-dimensional through-hole structure, and carrying out freeze-drying treatment to obtain the coaxial composite-structure bone tissue engineering scaffold. The coaxial composite-structure bone tissue engineering scaffold obtained by the preparation method satisfies mechanical property requirements and has good bone conduction performances and biocompatibility. The preparation method has simple processes, a low equipment cost and a great meaning for bone tissue repair.
Year: 2014
Country: CN
Doc No: 103536964