23 Jul Preparation method of caprolactone lactate copolymer/collagen/chitosan small-caliber intravascular stent
Abstract
The invention relates to a preparation method of a caprolactone lactate copolymer/collagen/chitosan small-caliber intravascular stent, and the preparation method comprises the following steps of: dissolving a caprolactone lactate copolymer into a solvent to obtain a caprolactone lactate copolymer spinning solution; dissolving collagen into the solvent to obtain a collagen spinning solution; dissolving chitosan into the solvent to obtain a chitosan spinning solution; and carrying out bidirectional electrostatic spinning by taking the caprolactone lactate copolymer spinning solution as a component I and a mixed solution of the collagen spinning solution and the chitosan spinning solution which have the volume ratio of 5-10:1 as a component II to obtain the caprolactone lactate copolymer/collagen/chitosan small-caliber intravascular stent. The biomaterial designed into a multicomponent gradient symmetrical structure has the advantages of better mechanical property and excellent biocompatibility and especially has the advantages of potential on accelerating cell three-dimensional ingrowth and important application in small-caliber vascular tissue engineering.
Year: 2013
Country: CN
Doc No: 103266421