23 Jul Preparation method of bionic injectable gelatin-silane composite medical hydrogel
Abstract
The invention discloses a preparation method of bionic injectable gelatin-silane composite medical hydrogel. The preparation method comprises the following steps: dissolving food and pharmaceutical grade gelatin powder in a phosphate buffer solution to obtain a gelatin solution; dissolving silane in a neutral phosphate buffer solution to obtain a silane solution; adding the silane solution into the gelatin solution according to a ratio of silane to gelatin of 0.5-2 ml to 1 g for carrying out a hydrolysis reaction to obtain transparent gelatin-silane composite sol; and gelatinizing the gelatin-silane composite sol at 37 DEG C. The bionic injectable gelatin-silane composite medical hydrogel disclosed by the invention contains no organic solvent or toxic component, and the formed composite medical hydrogel has high mechanical flexibility, maintains high stability in the phosphate buffer solution and has strong swelling resistance and approximately linear biodegradability; cell culture studies have shown that the bionic composite hydrogel prepared by the preparation method disclosed by the invention has good cell compatibility, thereby being capable of being applied to a variety of fields of soft tissue and bone tissue repair, tissue engineering and regeneration.
Year: 2014
Country: CN
Doc No: 103613769