23 Jul Preparation method of biomedical materials of multiclass functional group rich in amino group, carboxyl group and benzoquinonyl group
Abstract
The invention discloses a preparation method of biomedical materials of a multiclass functional group rich in amino groups, carboxyl groups and benzoquinonyl groups. The multiclass functional group rich in the amino groups, the carboxyl groups and the benzoquinonyl groups is constructed on the surface of a biomedical substrate material, the steps comprise soaking the substrate material in alkalinity Tris buffered solution of gallic acid with the concentration of 10ng/ml-20ng/ml in an environment rich in the amino groups, and reacting for 15min-30days to be sufficiently washed to obtain the biomedical material containing multiple functional groups. The preparation method has the advantages of being simple in operation, soft in reaction condition, easy to apply and controllable in functional group density process. Followed manufactured implantation instruments have good anticoagulation, endothelial cell adhesion, proliferation and migration functions are promoted, smooth muscle cell adhesion and proliferous functions are obviously restrained, and in-situ rapid induction endothelium functionalization of intravascular stents, intravascular stents and tissue engineering scaffolds which induce capillaries to form is achieved.
Year: 2012
Country: CN
Doc No: 102698322