23 Jul Preparation method of antibacterial biological activity ceramic coating with magnetic responsiveness
Abstract
The invention discloses a preparation method of an antibacterial biological activity ceramic coating with magnetic responsiveness, and belongs to the technical field of biological materials. The preparation method is combined with a layer-by-layer self-assembly technology by using ultrahigh adhesiveness of polydopamine so as to construct a coating of a multilayer film structure on the surface of a base material coated with a polydopamine film. A single layer film is prepared by coating polydopamine functionalized magnetic particle dispersion liquid, polydopamine functionalized antibacterial particle dispersion liquid or polydopamine functionalized biological activity ceramic particle dispersion liquid. The coating prepared through the preparation method has good biocompatibility, biological activity and antibacterial property, the coating can respond to an external magnetic field, and the effect of the external magnetic field can strengthen the osteoinductivity of the coating; the preparation method disclosed by the invention can effectively control the composition, thickness and shape of the coating according to actual requirements; the problems that the binding force between films formed by multilayer inorganic particles in the coating and the binding force between the coating and the base material are not strong are solved. The method has significant research value and clinical significance in bone tissue engineering.
Year: 2016
Country: CN
Doc No: 105920668