23 Jul Preparation method for tissue engineering transplant with micro-nano topological geometry structure on surface
Abstract
A preparation method for a tissue engineering transplant with a micro-nano topological geometry structure on the surface includes 1), preparing a silicone rubber seal with a micro-nano topological (three-dimensional) geometry structure pattern on the surface according to a micro molding method; 2), spraying a metal conducting nano-coating with the thickness of 50-100nm on the surface of the silicone rubber seal according to an ion sputtering method; 3), electrically spinning a natural or composite biological material solution onto the surface of the PDMS seal by an electrospinning technique toform a biological material support; 4), separating the spun biological material support from the PDMS seal to obtain the tissue engineering transplant with the micro-nano topological geometry structure on the surface. The preparation method has the advantages that the micro molding technology and the electrospinning technique are applied jointly, the spun biological material support is separatedfrom the PDMS seal easily, and the preparation method is simple and easy to operate and suitable for mass production.
Year: 2018
Country: CN
Doc No: 108525013