23 Jul Preparation method for preparing polylactic acid tissue engineering scaffold
Abstract
The invention relates to a preparation method for preparing a polylactic acid tissue engineering scaffold. According to the method, 25-40% of polylactic acid, 30-45% of polyoxymethylene and 25-40% of sodium bicarbonate are mixed up to prepare a mixed solution and then the mixed solution is subjected to spinning to obtain polylactic acid electrospun nanofibers. The nanofibers are processed in supercritical carbon dioxide. Through controlling the processing pressure and the processing temperature, an intermediate product is obtained. The obtained intermediate product is subjected to leaching in the circulating water bath and then drying in vacuum, and then the tissue engineering scaffold is obtained. The obtained tissue engineering scaffold is made of porous materials, wherein the porosity of the tissue engineering scaffold is 68 to 74.0% and the cell size of the tissue engineering scaffold is 20 to 200 microns. The dimension of the inner communicating channel of the tissue engineering scaffold is about 20 to 200 microns. According to the technical scheme of the preparation method in the invention, fibers can be cross-linked and fused at a relatively low temperature without any solvent or cross-linking agent. Meanwhile, the generation of cytotoxicity is avoided.
Year: 2017
Country: CN
Doc No: 106563172