23 Jul Preparation method for gelatin/hydroxyapatite composite coating
Abstract
The invention specifically relates to a preparation method for a gelatin/hydroxyapatite composite coating used for the surface of a bone tissue engineering scaffold. According to the invention, the composite coating is prepared through in-situ synthesis with a novel bone tissue engineering scaffold as a matrix material and gelatin, a calcium salt and phosphate as main raw materials; a calcium salt solution and a phosphate solution are added into a gelatin solution, and a composite coating solution is synthesized under the condition of heating; then the surface of the scaffold is subjected to amination and aldehydation modification; the gelatin/hydroxyapatite composite coating is finally loaded onto the surface of the scaffold; and since the surface of the scaffold is loaded with gelatin and nanometer hydroxyapatite, the defect of poor affinity between artificial synthetic high polymer materials and bone tissue is overcome, and the prepared scaffold can meet requirements of clinical medicine on cell affinity, biocompatibility and the like.
Year: 2017
Country: CN
Doc No: 106963984