23 Jul Preparation method for composite scaffold material based on collagen and collagen fibers
Abstract
The invention discloses a preparation method for a composite scaffold material based on collagen and collagen fibers; the preparation method is characterized in that collagen and aggregative-state structural body collagen fibers are mixed organically, functional oxidized polysaccharide and graphene oxide are used for composite synergistic modification of a collagen-collagen fiber composite solution, next, the collagen-collagen fiber composite solution is co-mixed with a certain amount of chitosan and polyvinyl alcohol, and then through 3D printing, microwave drying film formation, electric spraying, sterilization and other processes, the composite scaffold material based on the collagen and the collagen fibers is finally obtained. The material adopts the collagen fibers having a natural collagen structure and having stronger biomimetic property, the microstructure and morphology of the scaffold are biologically designed by using the 3D printing technology, natural active tissues are fully mimicked in the chemical composition and the natural structure, and the obtained scaffold material has the advantages of stable structure, superior physical and chemical properties, and good cell compatibility and biodegradability, also can induce tissue regeneration and repair, and can be used as various types of tissue engineering scaffolds.
Year: 2017
Country: CN
Doc No: 106693050