23 Jul Preparation method and application of functionalized graphene and calcium carbonate composite hollow microspheres
Abstract
The invention provides a preparation method and application of functionalized graphene and calcium carbonate composite hollow microspheres. The preparation method comprises the following steps: mixing functionalized graphene with a calcium salt solution in a container, and sealing the container by virtue of a paraffin sealing membrane; carrying out ultrasonic dispersion on the obtained mixed solution; forming a hole in the sealed part of the container containing the mixed solution, and putting the container into a closed container filled with concentrated sulfuric acid and ammonium carbonate; transferring the closed container into a constant temperature incubation box, and culturing; removing crystals produced in a gas-liquid interface by virtue of a cover slip, carrying out centrifugal separation on the mixed solution, and carrying out vacuum drying, so as to obtain the product. According to the preparation method, tetraethylenepentamine modified graphene is utilized as a template to induce calcium carbonate crystals to crystallize and grow; prepared calcium carbonate is a regular spherical hollow crystal, and the regular spherical hollow crystal has a relatively large specific surface area, a hollow structure and a rough surface structure, is good in dispersity and cytocompatibility, can be prepared into drug carriers or tissue engineering scaffold and can be applied to the medical field of bone tissues, and the crystal form is vaterite.
Year: 2016
Country: CN
Doc No: 105642202