23 Jul Preparation method and application of cartilage-inducing matrix material
Abstract
The invention belongs to the technical field of tissue-inducing biological material preparation, and particularly relates to a preparation method and application of a cartilage-inducing matrix material. The preparation method of the cartilage-inducing matrix material comprises the steps that calfskin is subjected to depilation, cutting, degreasing and heavy metal removal, and then sterilization, acid soaking and enzyme digestion treatment are carried out to obtain collagen liquid; finally, salting-out, purification, dialysis and neutralization are carried out on the collagen liquid to obtain the material. The matrix material prepared through the preparation method of the cartilage-inducing matrix material has the advantages of being high in bioactivity, good in biocompatibility and biodegradability and low in antigenicity, and the matrix material is used as a stem cell carrier and is induced for cartilage differentiation so that cartilage defects can be repaired and regenerated; the matrix material can also be used as a tissue engineering scaffold material, a soft tissue filling material and the like.
Year: 2019
Country: CN
Doc No: 109731136