23 Jul Preparation method and application of 4-trifluoroacetyl-7-oxo-1, 4-oxgyen nitrogen and high hydrogen hybrid
Abstract
The invention discloses a preparation method of 4-trifluoroacetyl-7-oxo-1, 4-oxgyen nitrogen and high hydrogen hybrid and an application of the 4-trifluoroacetyl-7-oxo-1, 4-oxgyen nitrogen and high hydrogen hybrid. The preparation method comprises the following steps of: (1) dissolving 1 mol of hydrochloric piperidone serving as the raw material into a solvent, adding 4-dimethylaminopyridine accounting for 0.05 to 5wt% of the raw material, adding 2 to 3 mols of triethylamine, and dropwise adding 1.5 to 2.5 mols of trifluoroacetic anhydride at 0 to 10 DEG C to react, and then cooling, and filtering to obtain a filtrate for later use; and (2) dissolving 1.0 to 2.5 mols of oxidant into the solvent, and dropwise adding into the filtrate prepared in the step (1) at 0 to 10 DEG C to react for 6 to 48 hours, thus obtaining the 4-trifluoroacetyl-7-oxo-1, 4-oxgyen nitrogen and high hydrogen hybrid. According to the preparation method of the 4-trifluoroacetyl-7-oxo-1, 4-oxgyen nitrogen and high hydrogen hybrid, a continuous material feeding method is adopted to form a novel structural hybrid which has yield up to 60%; the prepared monomer serves as the raw material to prepare a functionalized aliphatic polyester in a synthesizing way; the aliphatic polyester has high biocompatibility and high biodegradability, and the aliphatic polyester is applied to targeting drug carrier and tissue engineering, and also can serve as the sensitive material for an ion-elective electrode.
Year: 2012
Country: CN
Doc No: 102757401