23 Jul Preparation and application of bio-functional hydroxy propyl cellulose ester type liquid crystal membrane
Abstract
The invention discloses preparation and application for a bio-functional hydroxy propyl cellulose ester type liquid crystal membrane, and belongs to the field of biomedical materials. The preparation comprises the following steps: firstly, preparing a low-substituted alkyl acyl hydroxy propyl cellulose ester type liquid crystal by an acylating chlorination reaction of hydroxy propyl celluloses; reacting with glutaric anhydride and grafting a carboxyl functional group to the hydroxy propyl cellulose ester type liquid crystal; then preparing a liquid crystal membrane by adopting a solution pouring method; and activating the carboxyl on the surface of a thin membrane by EDC/NHS (carbodiimide/N-Hydroxysuccinimide) and carrying out a heterogeneous reaction with an oligopeptide containing RGDS (Arg-Gly-Asp-Ser) to obtain the bio-functional hydroxy propyl cellulose ester type liquid crystal with the surface which is grafted with the oligopeptide containing the RGDS. The liquid crystal thin membrane with the surface which is fixedly provided with the oligopeptide containing the RGDS has extracellular-matrix-like structure and component; the cell-material mutual effect is effectively improved; the adhering and the multiplication of cells on the surface of the material are promoted; the liquid crystal thin membrane can be used as a cell model or a cell bracket to be applied to the fields including tissue engineering, regenerative medicines and the like.
Year: 2014
Country: CN
Doc No: 103739866