23 Jul Porous calcium phosphate/gelatin composite scaffold for bone tissue engineering and preparation method of porous calcium phosphate/gelatin composite scaffold
Abstract
The invention relates to a porous calcium phosphate/gelatin composite scaffold for bone tissue engineering and a preparation method of the porous calcium phosphate/gelatin composite scaffold, and belongs to the field of application of a biomedical material technology. The composite scaffold is prepared by the following steps: steeping organic form obtained by laser processing and molding as a carrier into slurry containing calcium phosphate powder, and then carrying out the processes of heating, drying, thermal treatment and the like to prepare the porous calcium phosphate scaffold combining irregular through holes and regular straight through holes; and compounding the prepared porous calcium phosphate scaffold and gelatin to obtain the porous calcium phosphate/gelatin composite scaffold for bone tissue engineering, wherein the composite scaffold has a hole structure combining the irregular through holes and the regular straight through holes; the porosity is 70-95%; the apertures of the irregular through holes are 50-600 microns; and the apertures of the regular straight through holes are 0.4-1.8mm. The method is simple in process, convenient to operate and stable in yield; and the prepared scaffold is qualified in cytotoxicity and good in osteogenesis effect and has a good application prospect.
Year: 2016
Country: CN
Doc No: 105833345