23 Jul Polylactide fibrous membrane coated with glucan-g-poly(L-lysine)-VAPG/nucleic acid compound and preparation method
Abstract
The invention relates to a polylactide fibrous membrane coated with a glucan-g-poly(L-lysine)-VAPG/nucleic acid compound and a preparation method. The fibrous membrane is prepared from fibers with thediameter of 600-1,200 nm and glucan-g-poly(L-lysine)-VAPG/nucleic acid compound nanoparticles with the diameter of 50-100 nm and is 60-150 mu m thick. A nucleic acid compound solution coated with a glucan-g-poly(L-lysine)-VAPG polymer serves as a water phase, a PELCL or PLGA solution is taken as an oil phase, an electrospun fibrous membrane coated with a nucleic acid compound is prepared in an emulsion electrospinning manner, complete coating of nucleic acid is realized, the bioactivity of nucleic acid is protected, burst release of nucleic acid is relieved, the burst release rate is 20% or below, nucleic acid can be sustainably released to vascular smooth muscle cells in a controlled manner, and the polylactide fibrous membrane has good biocompatibility and biodegradability and can be used for the fields of tissue engineering and gene treatment.
Year: 2018
Country: CN
Doc No: 107551318