23 Jul Polylactide electrospinning composite film for in-situ gel encapsulating and preparation method thereof
Abstract
The invention discloses a polylactide electrospinning composite film for in-situ gel encapsulating and a preparation method of the polylactide electrospinning composite film. The electrospinning composite film consists of poly(lactide-co-glycolide) or polyethylene glycol-b-poly(lactide-co-caprolactone) fibers and chitosan or gelatin gel particles in the fibers. The preparation method comprises the steps that: sulfydryl chitosan or sulfydryl gelatin and polyethyleneglycol diacrylate are dissolved in phosphate buffer liquid to be used as water phases; the poly(lactide-co-glycolide) or the polyethylene glycol-b-poly(lactide-co-caprolactone) is dissolved in mixed organic solvents to be used as oil phases; and the water phases are added to the oil phases, water/oil (W/O) dispersing liquid is formed through adding emulsifying agents under the stirring condition, and the electrospinning composite film is obtained through the electrospinning of the dispersing liquid. The polylactide electrospinning composite film and the preparation method have the advantages that the preparation process is simple, the prepared composite film has good biocompatibility, degradability, hydrophily and mechanical property, the medicine dumping is reduced, and the medicine release speed is adjustable and controllable. The polylactide electrospinning composite film and the preparation method are used for the tissue engineering and medicine release fields.
Year: 2012
Country: CN
Doc No: 102505350