23 Jul Polyglutamic acid/sodium alginate adhesive hydrogel and preparation method thereof
Abstract
The invention relates to a polyglutamic acid/sodium alginate adhesive hydrogel and a preparation method thereof. Catechol groups with a tissue adhesion property are introduced in a poly(L-glutamic acid)/sodium alginate Schiff base gel system, and a first cross-linked network system is established through Schiff base crosslinking between hydrazide poly(L-glutamic acid) and oxidized sodium alginate; with the complexation of ferric ions as a second cross-linked network system, hydrogel is formed. Thus, catechol residues are retained as many as possible; meanwhile, a certain amount of ferric iron is mixed into the hydrazide poly(L-glutamic acid) component, the tissue adhesion of the catechol groups is exerted to the maximum, and tissue toxicity and other problems caused by conventional catechol oxidation crosslinking are avoided. The adopted materials have good biocompatibility, and various defects caused by oxidation crosslinking performed with oxidant are avoided; besides, adhesive elements are retained to the maximum, and the hydrogel has good application prospects in the tissue engineering field.
Year: 2017
Country: CN
Doc No: 106589409