23 Jul Polyethylene glycol chemical hydrogel based on enzyme cross linkage and preparation method of hydrogel
Abstract
The invention discloses polyethylene glycol chemical crosslinking hydrogel based on enzyme cross linkage. A preparation method comprises the steps of modifying phenolic hydroxy modified on a side chain of a polyethylene glycol linear polymer macromonomer solution, taking a horse radish peroxidase solution as a catalyst, and giving an in-situ enzyme cross-linking reaction in the presence of an enzyme catalysis reaction substrate, namely a hydrogen peroxide solution, to form a three-dimensional net structure. The prepared polyethylene glycol chemical crosslinking hydrogel has good biocompatibility, degradability and gel flexibility; physical and chemical properties such as gelation time and mechanical strength of the hydrogel can be regulated conveniently; and the hydrogel has wide application prospects in the fields of tissue engineering, drug controlled release, regenerative medicine and the like.
Year: 2018
Country: CN
Doc No: 108676179