23 Jul Polyester type polyurethane material with side chain containing phosphorylcholine group and preparation method thereof
Abstract
The invention relates to a polyester type polyurethane material with a side chain containing a phosphorylcholine group and a preparation method thereof. The preparation method comprises the following steps of: (1) causing polyester glycol react with excessive diisocyanate, thereby acquiring a double-end isocyanate group prepolymer; and (2) adopting a phosphorylcholine compound containing two amino groups for expanding the chain of the double-end isocyanate group prepolymer, thereby acquiring a biodegradable polyurethane material with the side chain containing the phosphorylcholine group. The phosphorylcholine group in the polyurethane material is located on the side chain of the polymer, so that the biocompatibility of the material can be effectively promoted under the condition of low content of the phosphorylcholine group. Soft segments of the material are all made from polyester; the degree of crystallinity is higher; the higher mechanical strength of the material is guaranteed; the main chain is fully hydrophobic; the degradation velocity is low; the polyurethane material, which is used as a tissue engineering repairing holder material, and the like, can be long-term applied to organism; after the material acts, the material can be gradually degraded into non-toxic products and then absorbed by the organism, so that the injury of the second operation can be avoided.
Year: 2017
Country: CN
Doc No: 106674486