23 Jul Polyamino acidic elastic vascular tissue engineering stent and preparation method thereof
Abstract
The invention discloses a polyamino acidic elastic vascular tissue engineering stent and a preparation method thereof; an inner layer is formed by compounding -NH<3+> in polysaccharide with -COO- in polyamino acid in an electrostatic compounding manner; an intermediate layer is a chemical crosslinking stent layer; an outer layer is an electrostatic spinning net; and the electrostatic spinning net is prepared from a poly(epsilon-caprolactone)-b-polyamino acid ester segmented copolymer through an electrostatic spinning method. According to the invention, the complex structure and the mechanical property of normal vessels are simulated; on one hand, the stent has good biocompatibility; the compliance of the stent can be well matched with a host vessel; on the other hand, the intermediate layer of stent has relatively good elasticity; under the dynamic stimulation of a vascular bioreactor, the stent can better bear wall-crossing pressure and resilience of a blood flow to a vascular wall; furthermore, the stent is deformed periodically, so that self remodelling can be strengthened; therefore, a regenerated blood vessel is closer to a normal blood vessel in tissue constitution; and furthermore, the polyamino acidic elastic vascular tissue engineering stent has excellent biomechanical property.
Year: 2015
Country: CN
Doc No: 104524641