23 Jul Polyamino acid-based self-healing hydrogel based on quadrupolar hydrogen bonding and preparation method of polyamino acid-based self-healing hydrogel
Abstract
The invention relates to a polyamino acid-based self-healing hydrogel based on quadrupolar hydrogen bonding. According to the polyamino acid-based self-healing hydrogel based on quadrupolar hydrogen bonding , polyamino acid is used as a main body material; taking biodegradable high molecular poly L-glutamic acid (PLGA) as an example, PLGA is modified with aminated polyethylene glycol (HAPEG) and methacrylate-based polyethylene glycol (MAPEG) to introduce 2-ureido-[4-hydrogen]-pyrimidinone (UPy), and a single-network self-healing hydrogel S-(PLGA-MAPEG-HAPEG)-g-UPy based on quadrupolar hydrogenbonding is obtained, and the hydrogel has excellent self-healing performance and shear thinning performance; and after ultraviolet irradiation, the mechanical property of double-network D-(PLGA-MAPEG-HAPEG)-g-UPy hydrogel is obviously improved. The double-network hydrogel has good biocompatibility and stability. After a hydrogel-cell compound is adopted for hypodermic injection of mice, a whole body is formed through self healing after being illuminated, and it is proved that the polyamino acid-based self-healing hydrogel developed in the invention has a potential application value in the field of tissue engineering.
Year: 2020
Country: CN
Doc No: 110845743