23 Jul Polyamino acid-based meniscus tissue engineering scaffold and preparation method thereof
Abstract
The invention discloses a polyamino acid-based meniscus tissue engineering scaffold and a preparation method thereof. The engineering scaffold is a skeleton-reinforced elastic support formed by filling a filling material in a multi-layered skeleton, wherein the skeleton is formed by bending a thin film which is prepared from chitosan through electrostatic spinning into a meniscus crescent structure, the filling material is a cross-linked network gel formed from poly (L-glutamate)-g-poly (e-caprolactone)/poly (L-aspartate)-g-poly (e-caprolactone) grafted copolymer and oligo-ethylene glycol cross-linking agent by virtue of a cross-linking reaction, and the elastic support is obtained through freeze-drying. The meniscus tissue engineering scaffold disclosed by the invention, which takes polyamino acid as a main material, is good in biocompatibility and biodegradability; the engineering scaffold can be used for providing mechanical support for joints, and the engineering scaffold can also simulate a normal meniscus to convert vertical pressure into horizontal annular stress, so as to effectively take a buffer action.
Year: 2015
Country: CN
Doc No: 104524639