23 Jul Platelet-rich plasma (PRP)-loaded pancreatic decellularized scaffold and preparation method thereof
Abstract
The invention discloses a platelet-rich plasma(PRP)-loaded pancreatic decellularized scaffold and a preparation method thereof and belongs to the technical field of pancreatic tissue engineering. PRPrich in various vascularization promoting growth factors is assembled in vessels of the pancreatic decellularized scaffold while human umbilical vein endothelial cell is planted in the vessels of thepancreatic decellularized scaffold, the loaded PRP is activated slowly by collagenous fiber of the pancreatic decellularized scaffold to releases a great quantity of growth factors slowly continuouslylocally, thereby providing an ideal environment for adhesion and proliferation of the human umbilical vein endothelial cell surrounding the inherent vascular networks in the scaffold; the PRP loadedpancreatic decellularized scaffold keeps the natural structure, biological characteristics and low immunogenicity of the pancreatic tissue; the growth factors which are slowly released continuously locally after the scaffold is transplanted in vivo have a remarkable vascularization promoting function; the scaffold is convenient to operate and has good controllability; generation of new vessels inthe scaffold is facilitated.
Year: 2020
Country: CN
Doc No: 110694114