23 Jul Photosensitive cyclodextrin polymer and nanoparticles thereof
Abstract
The invention discloses a photosensitive cyclodextrin polymer and nanoparticles thereof, which belong to the field of functional polymer materials. According to the photosensitive cyclodextrin polymer and the nanoparticles thereof, a natural plant monomer 3,4-dihydroxy cinnamic acid (caffeic acid, DHCA) is used as a raw material, a homopolymer PDHCA (poly(3,4-dihydroxy cinnamic acid)) of the DHCA is prepared by a gradual condensation polymerization method; a Michael addition reaction is carried out on the homopolymer and thiolated beta-cyclodextrin (6-SH-beta-CD) to prepare a photosensitive graft polymer (PDHCA-g-CD) with CD as a pendant group; the cyclodextrin polymers are self-assembled into nanoparticles under certain conditions and are crosslinked and immobilized by ultraviolet light; the grafting rate, the particle size and the ultraviolet light crosslinking degree of CD are controlled by adjusting the feeding ratio. The polymer and the nanoparticles thereof disclosed by the invention have excellent adsorption inclusion property, biocompatibility and biodegradability and can be applied in such fields as drug slow release systems, tissue engineering, environmental protection, etc.
Year: 2013
Country: CN
Doc No: 103450485