23 Jul Phosphoryl choline polymer containing aldehyde group and preparation method and application thereof
Abstract
The invention discloses a phosphoryl choline polymer containing aldehyde group, and the polymer is a binary copolymer composite synthesized of Vinyl monomers containing aldehyde group and Vinyl monomers containing phosphorus acyl choline through radical polymerization. Furthermore, the invention discloses the preparation method and the application of the polymer. The polymer is used for coating the surface of to-be-decorated material after being mixed with polyamino material, the reaction of the aldehyde group and the amidogen in the coating layer are controlled by temperature, so as to enable the density of the coating layer to be increased, and achieve the purpose of fixing phosphoryl bile bases on the surface of the material and obtain a coating layer with a structure imitating of cell outer membrane. The protein absorption and blood platelet adhesion of the coating layer are remarkably decreased, the biocompatibility is remarkably improved, and the phosphoryl choline polymer has great academic values and broad application prospects in the filed of tissue engineering, drug controlled release, gene therapy, biosensor and the like.
Year: 2013
Country: CN
Doc No: 103275269