23 Jul Phosphocreatine modified chitosan material, and preparation method and application thereof
Abstract
The invention discloses a phosphocreatine modified chitosan material, and a preparation method and an application thereof. The method comprises the following steps: dissolving chitosan in an MES buffering solution, grafting the chitosan with phosphocreatine through a zero grafting technique, carrying out dialysis, and then carrying out freezing and freeze-drying to obtain the phosphocreatine modified chitosan material. The material has the following various application prospects: when no double bond is introduced, the material is dissolved, and undergoes freeze-drying molding, a cross-linkingagent genipin is added to carry out cross-linking in order to obtain a porous scaffold, and the porous scaffold can be used for repairing non-bearing defect parts; and when the material reacts with methacrylic anhydride to introduce a double bond, the material is cross-linked and polymerized under ultraviolet lights to obtain injectable hydrogel, and the injectable hydrogel can be used for minimally invasive in-situ injection repairing of complex bone wounds. The modified chitosan material effectively overcomes the defects of poor effect and single form in bone repairing simply using chitosan,and can be used to prepare the porous scaffold, also can be used to prepare the injectable hydrogel, so the phosphocreatine modified chitosan material is of great significance to expanding the application of the chitosan material in bone tissue engineering.
Year: 2018
Country: CN
Doc No: 107903336