23 Jul PH-sensitive self-repairing hydrogel and preparation method of same
Abstract
The invention discloses a pH-sensitive self-repairing hydrogel and a preparation method of same. The hydrogel is produced by crosslinking dopamine-modified sodium alginate and sodium carboxymethylcellulose modified by 3-aminophenylboronic acid according to a certain ratio, wherein the modified sodium alginate and sodium carboxymethylcellulose respectively have a catechol group and a phenylboronic acid group, so that between the two groups, a pH-sensitive phenylborate bond can be formed. The phenylborate bond is fractured if pH < 7 and is recovered if pH > 7, so that the hydrogel has a pH-responded self-repairing performance. A main raw material of the hydrogel is natural polysaccharide, so that the hydrogel has excellent biocompatibility and also has pH-responding property and self-repairing performance. The hydrogel has wide applications in the fields of controllable release of drugs, tissue engineering and the like.
Year: 2017
Country: CN
Doc No: 106947094