23 Jul Oriented conductive collagen hydrogel, biomimetic conductive nerve scaffold material and preparation method of oriented conductive collagen hydrogel and biomimetic conductive nerve scaffold material
Abstract
The invention discloses an oriented conductive collagen hydrogel, a biomimetic conductive nerve scaffold material and a preparation method of the oriented conductive collagen hydrogel and the biomimetic conductive nerve scaffold material. The mixture of natural biological macromolecular collagen and polymer nanoparticles with excellent biocompability is used as a raw material, and oriented conductive collagen hydrogel fiber is prepared by a coaxial microfluidic chip with a PEG (polyethylene glycol) buffer solution; the biomimetic conductive nerve scaffold material with in situ loading of cellsis obtained by adding the cells in the process of hydrogel preparation. The hydrogel fiber prepared has the advantages of electrical conductivity matching with natural nerve tissue, similar mechanical properties, good biocompatibility, and can be arranged along the direction of the hydrogel fiber on a micro and nano scale, and can simulate the directional structure in the natural nerve tissue; the biomimetic conductive nerve scaffold material prepared can stimulate the arrangement of neurous in the nerve tissue along the direction of the nerve fiber and conduction of electrical signals alongaxons, and shows a good application prospect in the field of neural tissue engineering.
Year: 2019
Country: CN
Doc No: 110124113