23 Jul Novel tissue repair film
Abstract
The invention relates to the field of tissue engineering and regenerative medicine and designs a novel trilayer tissue repair film by constructing collagen-modified single-row high-molecular ordered fibers and bacterial cellulose and modifying the finished film with a static magnetic field generated by an added magnetic patch. An inner layer of the tissue repair film is made with the collagen-modified single-row high-molecular ordered fibers based on the action of fiber morphology upon cell behaviors, so that a binding site is provided for cells, and polar growth of the cells is induced. An intermediate layer is made with the bacterial cellulose, so that cell penetration is facilitated and a survival space is preserved for the cells. an outermost layer is made with the magnetic patch; thestatic magnetic field generated by the magnetic patch can produce a series of biological effects upon cells of living things. The novel trilayer tissue repair film is used mainly to regenerate skin tissue and repair skeletal muscular tissue. Based on structural optimization, the novel trilayer tissue repair film can be applied to tissue wounds, so that collected cells are regulated through the collagen-modified single-row high-molecular ordered fibers. finally, the behaviors of different cells in different tissue repair phases can be regulated through the series of biological effects which theapplied added magnetic field produces for the cultured cells.
Year: 2019
Country: CN
Doc No: 110201235