23 Jul Novel preparation method of beta-tricalcium phosphate/chitosan composite bionic hydrogel
Abstract
The invention relates to a novel preparation method of a composite bionic hydrogel. The described material is a beta-tricalcium phosphate/chitosan composite bionic hydrogel. The method comprises the steps of firstly dissolving chitosan by using a dilute acetic acid solution, dissolving beta-sodium glycerophosphate (beta-GP) into tri-distilled water, putting two parts of solutions into a refrigerator at 4 DEG C for storage overnight; adding beta-tricalcium phosphate to the chitosan solution under continuous stirring, carrying out ice-bath, adding a beta-GP solution, dropwise adding a little of glyoxal in a pH neutral environment, pacing the mixed solution at 37 DEG C overnight to form the hydrogel; and storing the hydrogel into the refrigerator at 4 DEG C to obtain the beta-tricalcium phosphate/chitosan composite bionic hydrogel material. According to the provided material, the part, requiring quick skeleton filling and bone tissue repairing, of an existing bone repair material is complicated, or an application limitation during minimally invasive therapy is overcome, and the preparation method is simple in process, low in cost and safe in synthesis, and has important application value in the field of biomedical engineering.
Year: 2017
Country: CN
Doc No: 107050523