23 Jul Novel physical hydrogel and usage thereof
Abstract
The invention discloses a novel physical hydrogel which is characterized by containing cholesterol-polyethylene glycol-cholesterol three-block compound. When the mass percent of the cholesterol-polyethylene glycol-cholesterol three-block compound in the hydrogel is 5-50%wt, the gel is formed; when the double-substituted substance has the concentration of 10-30%wt according to the different lengths of the chain segment of polyethylene glycol, the gel is formed at the room temperature; meanwhile, when the chain segment of the polyethylene glycol is 1.5-3kDa, the sol with the polymer content of 10-20%wt has sol-gel transition phenomenon at the temperature of 35-70 DEG C. The novel physical hydrogel is simple in preparation process, and the product is simple in purification operation; the prepared gel has controllable gel property and better biocompatibility, thus being used as biodegradation material; and the novel physical hydrogel has better biocompatibility, can be discharged outside by circulatory system and is free from long-term toxicity to the human body, thus being used as medicine gel formulation, embolic material and tissue engineering material.
Year: 2013
Country: CN
Doc No: 102863630