23 Jul New method for preparing temperature-sensitive hydroxybutyl chitosan
Abstract
The invention relates to a new method for preparing temperature-sensitive hydroxybutyl chitosan. A chitosan water solution is obtained by directly dissolving chitosan in an aqueous solvent at low temperature. The chitosan water solution further reacts with epoxybutane at room temperature. Inorganic components and unreacted impurities in a reaction solution are removed by dialysis, and white water-soluble hydroxybutyl chitosan can be obtained after freeze-drying. The derivative has the nature of being gelled when heated and being re-dissolved when cooled. Products with different phase transition temperatures can be obtained by controlling the feed ratio and reaction time. The hydroxybutyl chitosan prepared by utilizing the method has great water solubility. The preparation method is simple and easy to operate, the use of organic solvents can be avoided, and the reaction time can be greatly shortened simultaneously. As organic solvents are not used at all, the method has little influence on the environment. The hydroxybutyl chitosan prepared by the method provided by the invention can be used for the fields of medicament delivery, injection type tissue engineering scaffolds, bio-sensing and the like.
Year: 2014
Country: CN
Doc No: 103936887