23 Jul Natural polymer-hydroxyapatite bone tissue engineering scaffold material with secondary three-dimensional network structure and seed-crystal induction preparation method thereof
Abstract
The invention discloses a natural polymer-hydroxyapatite bone tissue engineering scaffold material with a secondary three-dimensional network structure and a preparation method thereof. The method comprises the following steps of: mixing hydroxyapatite nanorods and a natural polymer, crosslinking by utilizing a non-toxic crosslinking agent, namely genipin, freeze-drying to prepare a porous natural polymer scaffold with nanometer seed crystals, then biomineralizing by utilizing simulation body fluid, and forming a layer of hydroxyapatite nanometer three-dimensional network structure on the walls of porous channels of the natural polymer scaffold with a micron-level three-dimensional network structure under the induction of the seed crystals. The natural polymer-hydroxyapatite bone tissue engineering scaffold material with the secondary three-dimensional network structure not only has good biocompatibility, but also is non-toxic and has high bioactivity, which indicates that the materials are expected to be widely used in repair medicine.
Year: 2011
Country: CN
Doc No: 102107022