23 Jul Nanometer medicine delivery system based on PPV virus-like particles and preparation method and application of nanometer medicine delivery system
Abstract
The invention discloses a nanometer medicine delivery system based on PPV virus-like particles and a preparation method and application of the nanometer medicine delivery system. The nanometer medicine delivery system is composed of a nanometer carrier material and medicine. The nanometer carrier material is PPV virus-like particles decorated by TK peptide and is prepared through a baculovirus expression system. The medicine is micromolecule antitumor medicine and is wrapped by and loaded with the nanometer carrier material in a wrapping or covalent linkage mode. The TK peptide is targeted peptide. The amino acid sequence of the TK peptide is TWYKIAFQRNRK. The TK peptide and virus-like particles (VLPs) formed by capsid protein VP2 of procine parvovirus (PPV) are connected together through a gene engineering method to form the nanometer carrier material (TK-VLPs). The nanometer carrier system is wrapped by and loaded with medicine to form an active targeting nanometer medicine delivery system, and the medicine carrying TK-VLPs nanometer medicine delivery system has good tumor targeting and a strong antitumor growth effect, can better mediate nanometer medicine delivery system targeting tumor tissue, and has good research and application prospects.
Year: 2015
Country: CN
Doc No: 105194681