23 Jul Nanometer hydroxyapatite/chitosan/gelatin porous scaffold material and preparation method thereof
Abstract
The invention discloses a nano hydroxyapatite/ chitose/ gelatine composite porous bone tissue engineering cradle material and the preparing method. The material comprises chitose and gelatine with their mass ratio being 3:7-7:3 and the nano hydroxyapatite of 40-80nm deposited on the porous cradle material formed by chitose and gelatine. Preparing the porous cradle material with pore diameter 100-300 ª m and factor of porosity greater than 90% by using phase separation technique, then immersing it in the Tris buffer solution of Ca(NO3)2 for 10-12 hours, washing with deionized water three times and then immersing it in the Tris buffer solution of Na3PO4 for 10-12 hours, regulating pH value between 11 to 13, washing with deionized water three times and freezing for drying, then getting the nano hydroxyapatite/ chitose/ gelatine composite porous material by recycling the steps above several times, the size diameter of the hydroxyapatite is about 50nm, the material prepared in this invention possesses good mechanical property and biological compatibility.
Year: 2006
Country: CN
Doc No: 1799647