23 Jul Nano-micron multiscale tissue engineering composite three-dimension bracket and preparation method thereof
Abstract
The invention relates to a nano-micron multiscale tissue engineering composite three-dimension bracket and a preparation method thereof. Electrostatic spinning is performed under certain conditions to obtain a nano-micron chitosan sodium alginate composite fiber membrane; after the composite fiber membrane is subjected to alkaline washing and drying, the nano-micron chitosan sodium alginate composite fiber membrane is sheared into short fiber at high speed in water according to a certain proportion; after sample separation, calcium nitrate particles in micron scale are added as a pore-foaming agent; after freezing, drying and formation, water displacement is performed to remove the pore-foaming agent; then, freezing and drying are preformed to obtain the nano-micron multiscale chitosan sodium alginate composite three-dimension bracket. Chitosan and sodium alginate are compounded to overcome the defects of the chitosan and the sodium alginate. The preparation method has the advantages that the process is simple; the fiber diameter and the hole diameter of the bracket simultaneously have the nano-micron scale, so that good biology performance and mechanical performance are given to the composite brace.
Year: 2016
Country: CN
Doc No: 105664246