23 Jul Nano-calcium phosphate modified by polyethylene glycol phosphorous (phosphonic) acid dihydrogen ester and its preparation method
Abstract
The present invention discloses nano-calcium phosphate modified by polyethylene glycol phosphorous (phosphonic) acid dihydrogen ester, calcium phosphate can form a stable colloid in water or/and an organic solvent, its wide-angle X-ray diffraction displays diffraction peaks possessing characteristics of hydroxyapatite, or shows a wide dispersion peak of amorp hous calcium phosphate. The invention also discloses a preparation method of nano-calcium phosphate modified by polyethylene glycol phosphorous (phosphonic) acid dihydrogen ester. The polyethylene glycol phosphorous (phosphonic) acid dihydrogen ester used in the invention is added in the preparation process of nano-calcium phosphate, when the polyethylene glycol phosphorous (phosphonic) acid dihydrogen ester is grafted on the outer surface of nano-calcium phosphate, the interface energy of nano-calcium phosphate particles can be effectively reduced, thereby nanoscale dispersion in the water phase, organic phase or water/organic mixed phase can be achieved, and the two-phase interaction of the polymers can be increased. The nano-calcium phosphate is an ideal repair material for bone repair and bone tissue engineering, and the preparation method has the advantages of simpleness, maturation, energy saving and easy promotion.
Year: 2012
Country: CN
Doc No: 102558824