MULTI-VESICULAR LIPOSOMES FOR TARGETED DELIVERY OF DRUGS AND BIOLOGICS FOR TISSUE ENGINEERING

MULTI-VESICULAR LIPOSOMES FOR TARGETED DELIVERY OF DRUGS AND BIOLOGICS FOR TISSUE ENGINEERING

Abstract

A muitivesicular liposome composition includes a plurality of multi vesicular liposomes. Each multi vesicular liposome includes a carrier liposome particle including carrier phospholipid bilayer and having an average diameter less than 1 micron; and at least one sub-chamber liposome nanoparticle including a sub-chamber liposome nanoparticle bilayer and having an average diameter less than about 50 nm. The carrier liposome particle encapsulates the at least one sub-chamber liposome nanoparticle. Characteristically, tail groups of the carrier liposome phospholipids are larger than tail groups phospholipids of the at least one sub-chamber liposome nanoparticle.

Year:  2019

Country:  WO

Doc No:  2019210296

 

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