23 Jul Multi-armed polyglutamic acid taking beta-cyclodextrin as nucleus and injectable hydrogel and preparation method thereof
Abstract
The invention relates to a multi-armed polyglutamic acid taking beta-cyclodextrin as a nucleus and an injectable hydrogel and a preparation method thereof. The method comprises the steps that multi-aminated beta-cyclodextrin is synthesized first, multiple grafting reaction initiating loci are introduced, L-glutamate-N-carboxylic acid anhydride ring opening polymerization is initiated, hydroformylation modification is conducted on the multi-armed poly(L-glutamic acid), and the obtained product serves as a first component of the hydrogel; meanwhile, the poly(L-glutamic acid) subjected to amination modification serves as a second component, the two components are mixed according to a certain proportion, and the glutamic acid-based hydrogel is obtained through crosslinking in a Schiff base reaction, wherein the gelation time ranges from 20 s to 400 s. The hydrogel has the advantages that the hydrogel has good biocompatibility and biodegradability and can adapt to different shapes; in addition, due to the fact that beta-cyclodextrin is introduced, crosslinking points can be increased, improvement of the mechanical strength of the hydrogel is promoted, and loading and release control can be conducted on hydrophobic drugs. Therefore, the hydrogel has wide application prospects in the fields of tissue engineering, regenerative medicine, controlled drug release and the like.
Year: 2016
Country: CN
Doc No: 106117547