23 Jul MODIFIED SUPEROXIDE DISMUTASE
Abstract
PURPOSE:To obtain a modified SOD by bonding an SOD useful for the remedy of tissue disorder caused by O2<-> generated from oxygen molecule in a living body with a compound having pharmacological activity and useful as a drug. CONSTITUTION:A modified SOD (superoxide dismutase) is produced by bonding a carboxyl group (or amino group) of a compound having physiological activity to an amino group (or carboxyl group) of SOD using a carbodiimide and separating and purifying the objective substance e.g. by gel-filtration. The physiologically active compound is those having a molecular weight of 150-400, exhibiting anti-inflammatory action and having functional group such as amino group, carboxyl group, etc., e.g. indomethacin or ketoprofen. The SOD used as a starting material is human SOD produced e.g. by genetic engineering technique. The amount of the physiologically active compound to be bonded to SOD is preferably 1-10mol. per 1mol. of SOD.
Year: 1988
Country: JP
Doc No: S63313581