23 Jul Microcarrier as well as preparation method and application thereof
Abstract
The invention discloses a microcarrier as well as a preparation method and application thereof. The particle size of the microcarrier is 50-1000mu m, the size of pores on the surface of the microcarrier is 0-500mu m, the interior of the microcarrier has a porous structure, and the microcarrier is prepared by the steps of preparing a mixed-phase solution and preparing the microcarrier. Specifically the preparation method comprises the following steps: dissolving a polymer and a foaming agent in solutions with different polarities, mixing the two phases of solutions uniformly by using high-speed homogenate stirring, then injecting the mixture into a surfactant aqueous solution, performing uniform mixing and after treatment to obtain the microcarrier of which the surface pores are closed or opened, performing mixing stirring on the microcarrier of which the surface pores are closed and an alkali or acid solution, and performing after treatment to obtain the microcarrier of which the surface pores are opened. The preparation method disclosed by the invention is simple in operation, and the prepared microcarrier is diversified, is degradable in material and good in biocompatibility, and can be widely applied to the aspects of cell culture, medicine slow release, tissue engineering materials, catalyst carriers and the like.
Year: 2017
Country: CN
Doc No: 106620710