23 Jul Micro RNA for accelerating tissue-engineered bone vascularization and application thereof
Abstract
The invention discloses micro RNA for accelerating tissue-engineered bone vascularization and application thereof and belongs to the technical field of gene engineering. The micro RNA is miR-26a, and the sequence is shown as SEQ. ID. NO. 1. The micro RNA for accelerating the tissue-engineered bone vascularization uses a mice skull defect regeneration model, preferential expression of the miR-26a is discovered in new bone, after transferring the miR-26a mimics and inhibitor into cell in vitro to realize the miR-26a expression increasing and decreasing, observing the regulation effect of the miR-26a for growth factors related to the angiogenesis in vitro in three osteogenesis related cell models, and using an in vivo and in situ bone defect and ectopic bone regeneration model to further verify the vascularization accelerating effect of the miR-26a in vivo.
Year: 2015
Country: CN
Doc No: 104694542